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Oxford's coronavirus vaccine shows promise in animal trials

The preliminary findings also indicated that the "ChAdOx1 nCoV-19" vaccine has been effective in preventing damage to the lungs.


Coronavirus vaccine



The first results of a recent animal trial of coronavirus vaccine from Oxford University have shown promising results.The report showed that the monkeys given a single shot of the vaccine developed antibodies against the virus within 14 days. Protective antibodies were developed by all monkeys within 28 days before being exposed to higher doses, it added. The preliminary findings also indicated that the "ChAdOx1 nCoV-19" vaccine has been effective in preventing damage to the lungs.

"The most important finding to me is the combination of considerable efficacy in terms of viral load and subsequent pneumonia, but no evidence of immune-enhanced disease, which has been a concern for vaccines in general, for example with vaccines against respiratory syncytial virus (RSV), and for SARS vaccines," Prof Stephen Evans, Professor of Pharmacoepidemiology, London School of Hygiene and Tropical Medicine, said.

The potential for antibody-dependent enhancement of the disease is considered as one of the key challenges with vaccines against the coronavirus species, the experts said. It has been a primary reason for the lack of a vaccine against the 2003 SARS CoV strain, they added.


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Oxford University's Covid-19 vaccine test on monkeys shows promise


The UK's biggest COVID-19 vaccine project, currently being tested by the University of Oxford, has shown some promising results in a small study with monkeys.




The UK's biggest COVID-19 vaccine project, currently being tested by the University of Oxford, has shown some promising results in a small study with monkeys.

Researchers involved with the ChAdOx1 nCoV-19 trials said the vaccine had shown signs of priming the rhesus macaque monkeys’ immune systems to fend off the deadly virus and showed no indications of adverse effects.

According to the study, which is yet to be peer-reviewed, a single vaccination dose was also effective in preventing damage to the lungs organs that can be severely affected by the virus.

"A single vaccination with ChAdOx1 nCoV-19 induced a humoral and cellular immune response in rhesus macaques," the authors said.

"We observed a significantly reduced viral load in bronchoalveolar lavage fluid and respiratory tract tissue of vaccinated animals challenged with SARS-CoV-2 (COVID-19) compared with control animals, and no pneumonia was observed in vaccinated rhesus macaques," they said.

The researchers found that after being exposed to high levels of the novel coronavirus, none of the six monkeys that were given the vaccine developed viral pneumonia. Also, there was no sign that the vaccine had made the animals more vulnerable.


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